Slow and steady
A single injection of a large insulin aggregate into diabetic animals can allow for long-term regulation of their blood glucose levels
A team of scientists from India has found that one injection of a specially formulated insulin aggregate into diabetic animals can lead to steady release of insulin into the blood for over 100 days1. If the findings can be extended into humans, this insulin aggregate formulation could revolutionize diabetes treatment by drastically reducing the number of insulin injections that diabetic patients need to administer.
Current treatment calls for multiple daily injections of the hormone insulin, which is a high burden for patients to endure. The inability of diabetes patients to regulate their blood sugar levels can lead to complications such as nerve damage, kidney failure and cataracts.
Insulin is responsible for pulling glucose out of the blood and into all of the body's cells. The insulin that is currently used for diabetes treatment is made up of single insulin peptides in solution. However, insulin peptides can aggregate into larger structures. The researchers thought that these larger aggregates could allow for slow and steady release of insulin peptides.
When they injected the insulin aggregate into diabetic animals, this allowed for long-term control of blood glucose levels, and a decrease in the incidence of cataracts and other complications in the animals.
Authors and Affiliations
- National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
- Molecular Biophysics Unit, Indian Institute of Sciences, Bangalore 560012, India
1 comment:
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